Patients treated on a Phase-I clinical trial of photodynamic therapy (PDT) developed a systemic capillary leak syndrome that constituted the dose-limiting toxicity. Extrapleural pneumonectomy permits more effective radiotherapy dose delivery for malignant pleural mesothelioma.
The hope is that mesothelioma patients will also benefit as the length of time increases for survivors of all forms of this complex cancer. Gene therapy to correct gene mutations caused by cancer cells, and molecular chemotherapy to direct therapeutic cells against tumor cells and leave healthier cells. The many ways of treating mesothelioma have led to advances and experimental therapies such as photodynamic therapy, immunotherapy, and gene therapy.
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